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An Eco-friendly Herbal Acaricide to Control Ticks Including Acaricide Resistant Species Infesting Livestock and Pet Animals
Novel and chemically characterized anti-tick Phyto-formulation. Extracted from commonly available plant, herbaceous in nature, widely available across the country, plants require very low agronomical conditions to grow.
Effective against acaricide-resistant ticks.
Having fly repellent properties. Having less chance of
development of resistant to the developed formulation as
it contains many active principles showing anti tick activity.
Safe for animal application (as per OECD guidelines 404, 410, 423).
Stable at different temperature condition without losing anti-tick activity.
Quality control ma rkers identified. Management of ticks including acaricide
resistant species. Reduce indiscriminate use of synthetic acaricides.
No residual toxicity in milk and meat products, thus it will increase
the acceptability of Indian dairy products in the global market.
Reduce environmental pollution and maintain food chain. Less chance
of development of resistance in target species. Having fly repellent
properties. Multi-locational field trials of the developed formulation
were conducted in organized and unorganized dairy farms of Punjab, Rajasthan,
Haryana and Uttar Pradesh where commonly used acaricide were not working
effectively against tick infestations in animals. The tick population of
these locations was found resistant to SP and OP compounds. The clinical
efficacy of the formulation was more than 80% against
natural tick infestation. The working Phyto-formulation was found safe
(OECD guidelines 404, 410, 423) for animal application.
It was also stable at 0-4°, 37° and 60°C temperature for
30 days showing consistent anti-tick activity without any
significant variation. In vitro anti-tick activity: The LC90 value
against reference susceptible IVRI-I tick line was determined as 8.5%.
Formulation is 50-75% efficacy against highly resistant IVRI-IV tick line
having resistance factor of 194.0 against commonly used deltamethrin.
This level of resistance usually does not exist in the field situation.
The formulation showed efficacy (>75%) against multi-acaricide resistant
IVRI-V line along with inhibition of oviposition. Similarly, the formulation
was 75-80% effective against field collected ticks having different level
of resistance to pyrethroids and OP compounds. Formulation showed 70-80%
efficacy against buffalo lice, dog tick (R. sanguineus) and
multi-host tick species, Hyalomma anatolicum. In vivo efficacy:
In vivo experimental trial was conducted as per the laboratory
standardized method. Under experimental high challenge condition,
the efficacy (E%) of the Phyto-formulation was within the range of 67 to 75%.
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Mesenchymal Stem Cell Condition Media Based Formulation for Wound Healing
Treating skin wounds with minimal scar formation is a
challenge in human as well as in veterinary medicine.
Though, stem cell therapy has been proved to heal wounds
faster with minimum scar formation but due to possibility
of immune rejection, more technicalities in application,
and being costly affair it is still not much popular
amongst livestock and pet owners. While conditioned
media has no such problems. The most accepted
mechanism of action of MSCs in regenerative therapy is due to secretions
from these cells, as these cells are well known for
secreting various growth factors and cytokines in response
to environmental cues and thus proposed to secrete these
growth factors and cytokines in culture media
(Dvorak et al., 2005; Ansari et al., 2013; Joseph et al.,
2020). Using stem cell conditioned medium is as a novel
and promising alternative. It improved wound healing rate
with very less scar formation and can be applied in
allogenic as well as in xenogenic mode without immune
rejection problem and also cost effective than stem cells
therapy.
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Bio mesh scaffold augmented with mesenchymal stem cells conditioned media for quality wound healing
Mesh scaffolds are commonly used to provide a physical
support in a weakened tissue. Biological materials have
been introduced as an alternative because of their higher
biocompatibility. Biocompatible mesh material augmented
with stem cells conditioned media containing a battery
of growth factors and cytokines, has better regenerative
capacity by reducing the inflammatory reaction and
improves healing rate and healed wounds are with minimum
to nil scar. It is a product, augmented with rich
mitogenic cocktail. It has enriched growth factors
and cytokines with the capability of mechanical
strengthening and immunomodulatory property of
biomesh as well. Bio-mesh augmented with conditioned
media derived from bone marrow mesenchymal stem cells
for clinical applications to improve wound healing in
animals. It can be used by pharmaceuticals, clinicians
in veterinary/animal as well as in medical sciences.
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IVRI-Anti Diarrheal Herbal Formulation (ADHF)
Diarrhoea in animals, especially in the new born calf,
is a major problem resulting in great economic loss
to the livestock industry. Beside the specific oral
antimicrobial therapy, correction of the associated fluid,
electrolyte and acid-base imbalances by the use of
supportive therapies are the most needed life saving
measures. Indigenous herbal preparations to treat
diarrhoea are an age old practice. It can be an
appropriate sustainable eco friendly and cost-effective
alternative to limit the sole dependency on chemical
agent. An ideal polyherbal anti diarrheal formulation
has been developed to control calf diarrhoea by Indian
Veterinary Research Institute (ICAR) maintaining GLP and
GMP using locally ava ilable plant materials.
Uniqueness of newly developed herbal formulation was
to bring the faecal consistency to normal by day 3 of
treatment along with marked improvement in dehydration
and depression scores also. It has profound economic
significance to organized and unorganized herd.
Formulation developed by IVRI would be cheaper than
equivalent herbal formulation produced outside India
if any. Extensive on field therapy in various agro
climatic zones has been done denoting better effect
even than modern medicine. A complete know how document,
including standard usage, training and demonstration
is covered under the offer.
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IVRI-Herbo Mineral Acaricide Formulation
Tick control programme was ranked high in terms of
their impact on the livelihood of resource poor
farming communities in developing countries including
India. Resistance to existi ng chemical acaricides is
widespread and newer classes of acaricides have tended
to be significantly more expensive. Use of herbomineral
acaricide can be an appropriate sustainable environment
friendly and cost effective alternative to limit the sole
dependency on chemical acaricides. An ideal polyh
erbomineral acaricide has been developed to control
cattle tick by Indian Veterinary Research Institute
(ICAR) maintaining GLP and GMP using extracts of locally
available plant materials and commonly known minerals.
Uniqueness of newly developed herbomineral acaricide
possesses remarkable antifeedant, anti ovipositional
and fecundity reducing property to limit the tick
population even in the next generation of survived ticks.
It has profound economic significance to tropical
countries especially in India, other Asian countries
and African Continent. Formulation developed by IVRI
would be cheaper than equivalent herbal acaricide
produced outside India if any. Extensive on field
trial in various agro climatic zones by topical
application has been done depicting better effect
even than modern chemical acaricide. A complete know
how document, including standard application procedure,
training and demonstration is covered under the offer.
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Novel anti tick phyto pharmaceutical formulations (TK-5, TK-10, TK-C) against tick infestations in livestock and pets animals
Eco-friendly, safe and chemically characterized acaricidal phytopharmaceutical.
Formulations (cream and flowable) prepared from widely available
herbaceous plant. Effective against Synthetic pyrethroids,
Organophosphate and Ivermectin resistant ticks infesting
livestock and pet animals. As the lead compounds are acting
synergistically, the chances of development of resistance in
ticks is comparatively low. The animal products will be free
from residual toxicity. Production cost is optimum.
No dedicated facilities is to be created for commercial production
of the formulation in the existing infrastructure of market players.
Stable at different temperature conditions without losing antitick
activity. Patent application n o. -202011053602.
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Herbal Product for amelioration of Fluorosis in animal
Man and animals are exposed to excess fluoride
largely due to industrial activity and consumption
of fluoride rich water and vegetation. At present,
problems of fluorosis have been reported from 21
states of India. Fluoride is a cumulative Poison
and caused toxic effect to bone, muscle, teeth,
liver, nerve and reproductive organs. Till date there
is no specific antidote and drug for treatment of
fluorosis in man and animals. Division of Medicine
has developed an herbal product which can remove
Fluoride from animal body and help ameliorating
deleterious effect of excessfluoride. The product
has no side effect and completely safe for long term
use in animals This specific combination of herbal
extracts could remove the fluoride from bone and serum
by augmenting excretion of fluoride in
Urine as a result, the residue and toxic effects
decreases in animals daily The product should be
used daily till the Fluoride concentration in blood
reduced below 0.2- 0.25 µg/ml