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Major Achievements

  • One virulent strain of duck enteritis virus (DEV) has been isolated and confirmed by molecular characterization and pathogenicity test (DEV/India/IVRI-2016; Acc. no. KX511893) along with its complete genome sequencing (GenBank no. MZ824102).
  • The cell culture attenuated vaccine candidate (strain: DPvac/IVRI-19) has been developed using the Indian field isolate (DEV/India/IVRI-2016) by serial passages in primary CEF cell cultures. The complete genome sequence of this vaccine candidate is available in GenBank (MZ911871).
  • The indigenous duck plague cell culture vaccine (DPvac/IVRI-19) was found to be completely safe and afforded 100% protection.
  • Poly-lactic-co-glycolic acid (PLGA) nanoparticles encapsulating inactivated NDV was successfully prepared and characterized.
  • Intramuscular immunization with nano-encapsulated NDV elicited protective levels of HI antibody (28), maintained up to 8th wk PI, along with cell mediated immunity and afforded 90% protection against NDV.
  • Developed a recombinant penton protein based indirect ELISA for the detection antibodies against Egg-drop-syndrome (EDS76) in chicken.
  • Demonstrated the synergistic interaction of LPS (TLR4 agonist) and resiquimod (TLR7 agonist) in chicken both in vitro and in vivo.
  • Resiquimod was found to induce Th1 as well as Th2 immune responses in chicken
  • Adjuvant potential of resiquimod (R-848) with inactivated NDV vaccine was demonstrated in SPF chicken.
  • Resiquimod was proven to have prophylactic potential against vvIBDV challenge in chicken.
  • Resiquimod was found to enhance antigen specific systemic as well as mucosal immunity against avian infectious bronchitis in chicken.
  • Poly I:C alone and its combination with Pam3CSK4 were found to significantly reduce the immunosuppression when used with an intermediate plus IBDV vaccine in chicken.
  • Canine parvovirus specific neutralizing avian egg-yolk derived IgY antibodies have been developed.
  • Three recombinant truncated VP2 proteins of canine parvovirus (CPV) was expressed in prokaryotic system (E. coli) and used in the development of latex agglutination test (LAT) and lateral flow assay (LFA) for detection of specific antibodies and antigen respectively.
  • Host restriction of Salmonella Gallinarum to chicken is related to its capacity to interfere the function of dendritic cells was established.
  • Role of reactive oxygen species (ROS) in modulation of chicken dendritic cell function was established.
  • Novel aptamers specific to canine parvovirus have been identified.
  • Three different batches of novel LSAg were developed and tested on 50 CSFL/CSML farm laying hens. The diagnostic ability was comparable to the p27 based commercial ELISA kit (M/s IDEXX Laboratories)