Indian Veterinary Research Institute
भारतीय पशुचिकित्सा अनुसंधान संस्थान

Pharmacology & Toxicology Division

Major Achievements

Research
  • Palasonin isolated from the seeds of Butea frondosa was shown to possess anthelmintic activity.
  • Andrographolide isolated from Andrographis paniculata possessed analgesic and anti-inflammatory activity.
  • Uterine smooth muscle activity in experimental (rat) and farm animals (goat) during late gestation was worked out.
  • Pinacidil and Mibefradil were shown to possess tocolytic activity on goat uterus.
  • Bay-41-2272, a vasodilator dilated sheep pulmonary artery through the activation of sodium pump. This is of significant importance in pulmonary hypertension.
  • L-Arginine , sodium nitroprusside, levcromakalim and pinacidil dilated goat coronary artery in-vitro involving cGMP and KATP channel pathways.
  • Heat stress impaired cerebral circulation in chicken by constricting carotid arteries through enhanced reactivity to serotonin.
  • Neuro-pharmacological investigation on amphistome and liver fluke revealed the important role of serotonin, dopamine and acetylcholine.
  • Essential oil of Allium sativum and Piper longum inhibited spontaneous muscular activity of Fasciola gigantica.
  • Arsenic, lead and cadmium induced apoptosis in splenocytes from experimental animals, subjected to sub-acute toxicity.
  • Pharmacokinetic parameters of fluoroquinolones were established in goats and poultry.
  • Drug and xenobiotic residues were monitored in meat and meat products.
  • The role of nitric oxide in neuropathic pain has been established.
  • N-acetyl cysteine ameliorated neuropathic pain.
  • Neuroprotective effect of s-methyl thiourea was demonstrated in stroke model.
Teaching/Human Resource Development

The Division has produced 24 M.V.Sc and 23 Ph.D students in the last five years and they are placed at various National and International Labs. Twelve students were selected as scientists, 6 students as Assistant Professors, 9 students as Veterinary Officers, one in civil services as Indian Forest Officer, 9 students as Post Doctoral Fellows and 8 students as Ph.D scholars abroad

Training/Seminars

The Division has conducted one National Seminar and one Winter School during the last five years.

Publications

Division has published 52 International and 13 National Research Papers during last five years

Patents

Division has been granted one patent and one patent is in process.