Research Achievement- IVRI Izatnagar

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About IVRI

Achievements

The institute with its long heritage and glorious scientific achievements has always enjoyed a certain prestige and tradition of its own. The institute at its headquarters functions through more than 20 research divisions, 400 acres livestock and fodder production farms, feed technology unit, a modern computerised library, engineering section, medical hospital, etc. Besides the main campus, three regional stations at Kolkata, Palampur and Srinagar and two full-fledged campuses at Mukteswar in Uttarakhand and Bangalore in Karnataka are the other functional units of the institute dedicated to livestock research and development. Further, the institute is the seat of two Centres of Advanced Faculty Training (Formerly Centres of Advanced Studies) in Animal Nutrition, and Veterinary Physiology, many a Network outreach programmes, National Agricultural Innovation Projects and All India Co-ordinated Research Projects.

IVRI Lab The institute, the largest of its kind in whole of South-east Asia, is widely known for its impressive contributions to all aspects of livestock and poultry health, production technology and postgraduate education. The Institute is a pioneer not only in mission-oriented research, but also a foremost centre for postgraduate training and education. For many in the profession it is their Alma Mater.

The institute takes a legitimate pride in its contributions and distinguished services pro rata in achieving the national goals. With the richest animal resource in the world today, India is the largest milk producer and ranks fourth in egg production and fifth in broiler production in the world. These notable achievements became a reality due to direct impact on account of control of major diseases, particularly rinderpest and CBPP in cattle, African horse sickness in horses and Newcastle disease in poultry as a result of potent vaccines developed by IVRI. Some of the salient achievements are summarised below:

A. Animal Health

Early Interventions - Pre-independence Phase

Development of anti-rinderpest serum (1899), anti-anthrax serum for cattle (1902), haemorrhagic septicaemia (HS) serum (1905)
Development of black quarter vaccine (1906-08)
Treatment of surra (T. evansi infection) in horses and camels (1908-11)
Production of polyvalent HS vaccine (1908)
Eradication of dourine in horses (1920-21)
Development of goat tissue vaccine (GTV) against rinderpest (1927)

Sustained R&D Activities - Post-independence Phase

Development and updating FMD vaccines including crystal violet tongue epithelium (1946-52), goat kidney cell culture (1964-65), saponin and oil adjuvant (1968-70) and BHK-21 monolayer and cell suspension (1971-78) vaccines
Development of anthrax spore vaccine (1951)
Control and eradication of African horse sickness through appropriate diagnostics, vaccine and control strategies (1960 - 65)
Development of an irradiated sheep lung worm vaccine (1973)
Standardization of fermenter technology for large scale production of FMD vaccine in BHK-21 (clone 13) cells in suspension (1976-79)
Development of Theileria schizont vaccine for bovine theileriosis (1979)
Development of inactivated goat pox vaccine (1986-87)
Successful use of horn plates in the management of long bone fractures in animals (1986-90)
Development of drugs/formulations from indigenous medicinal plants for skin infections, ecto-and endoparasites and wounds (1990-96)
Molecular characterization and differentiation of P. multocida strains, Salmonella serovars of veterinary and zoonotic significance using ribotyping, PCR and DNA fingerprinting techniques (1992-2000)
Development of ELISA technology for diagnosis of salmonellosis, brucellosis, listeriosis, theileriosis, babesiosis, trypanosomosis, fasciolosis and echinococcosis (1995-99) and inclusion body hepatitis-hydropericardium syndrome (IBH-HPS) in chicks (2000)
Discovery and documentation of the medicinal value of indigenous plants viz., Cissus quadrangularsis (Hadjore), Ocimum sanctum (Tulsi), Pongamia pinnata (Karaei), Delonix regia (Gulmohar), Mongifera indica (Aam) and Asparagus racemosus (Shatavar) (1995-99)
Development of monoclonal antibodies against P. multocida (1994-95), foot and mouth disease virus O,A,C and Asia-1 (1994-96), bovine herpes virus-1 (1995-96), Salmonella Enteritidis (1996-97), buffalo pox virus (1998-99)
Development and release of a COFAL test kit for detection of ALC infection in poultry (1997).
Olinall®, a formula for treatment of chronic skin ailments commercialized (1997)
Development of a panel of hybridoma antibodies against rinderpest virus and a MAb based competitive ELISA to distinguish between rinderpest and PPR (1997-99)
Development and release of a kit for diagnosis of bluetongue (1998), FMD (1998), rinderpest (2001)
Demonstration of 'lead' as an inducer of oxidative stress in bovines for the first time (1998-99)
Development of PCR assay and a non-isotopic gene probe for detection of Trypanosoma evansi (1998-2000)
Development of IBD vaccine (1999) and a thermostable IBD vaccine (2001) for gumboro diseases of poultry (1999)
Standardization of ELISA and PCR for the diagnosis of Mycoides clusters of Mycoplasma viz., Mycoides mycoides Subsp. capri, M. mycoides Subsp. mycoides Type LC, M. capricolum Subsp. capricolumn, M. capricolum, Subsp. capripneumoniae and Mycoplasma sp. bovine group 7 (1999)
Designing and fabrication of an external skeletal fixation device for stable fixation of metatarsal and radial fractures in large animals (1999)
Development of CCPP vaccine for goats and sheep (2000)

Development of Rose Bengal coloured antigen for serum agglutination test (1999-2000) and kit for diagnosis of caprine pleuropneumonia
Occurrence of chicken infectious anaemia (CIA) in India by PCR assay and isolation of virus (2000)
Development of an inactivated oil emulsified vaccine against IBH-HPS (2000)
Targeted PCR assays for detection of haemoprotozoan infections caused by Theileria annulata and Babesia bigemina infected carrier animals were standardized (2001)
PCR based diagnostic technology developed for the detection and differentiation of important avian diseases viz., infectious bursal disease, CIA, Newcastle disease, EDS-76 virus syndrome, Avian Reovirus infection and duck plague (2001)
Development of an effective indigenous treatment for endometritis in buffaloes (2002)
Development of DNA vaccines against canine parvo virus and IBD virus (2003)
Development of ELISA technology for diagnosis of BVD, PPR and PPRS (2003)
Development of PCR based diagnostic technology for fowl adeno virus-4 (2003)
PCR based diagnostic assays standardized for BPV, BVD virus, canine parvovirus, Campylobacter (2003), Brucella and Haemonchus contortus (2006)
Development of area-specific mineral mixtures to improve animal health and production (2003)
Conferment of 100 per cent protection in challenged calves by a low volume (2 ml) saponified haemorrhagic septicaemia vaccine, up to 12 months post immunization (2004)
Conferment of 100 per cent protection in mares challenged with a virulent S. Abortus equi strain by defined deletion double mutant vaccine for Salmonella Abortus equi (2004)
Development of Dot-ELISA for quick diagnosis of PPR infection in small ruminants (2004)
Successful fixation of fractures in dogs with osteopenic bones by modified technique of interlocking nailing (2004)
Commercialization of area specific mineral mixture with industrial concerns (2005)
Commercialization of IVRI crystoscope with corporate agencies (2005)
Development of multiplex PCR for listeriosis and nested PCR for BDV, BVDV (type 1 & 2) and T. evansi (2006)
Detection of H5N1 strain of influenza virus in poultry for the first time in the country as a result of extensive field and laboratory investigations. Four H9N2 and one H9N1 viruses were isolated (2006)
Development of Real-time PCR based diagnostic assays for important exotic diseases namely, avian influenza virus and pseudorabies (2006)
Recombinant diagnostic antigens viz., FMDV (P1) polyprotein, PPR (H protein), RD (HN protein), brucellosis (L7/L12 ribosomal protein) and IBD (VP2) protein) were isolated (2006)
A status of freedom from contagious bovine pleuropneumonia infection in cattle and buffalo was obtained from OIE (2007)
Dot-ELISA was developed for serodignosis of Fasciola gigantica infection (2007)
Development of cell culture vaccine for classical swine fever (2007).
Development of recombinant antigen based ELISA kit for serodiagnosis of IBD and NDV (2007)
Epoxy-pin external skeletal fixation technique has been developed for a variety of compound fractures of long bones in small animals (2007)
A novel design of bilateral external fixator has been developed for the management of long bone fractures in large animals (2007)
A Taqman based one-step Real-time RT-PCR was developed for simultaneous detection and genetic typing of ruminant pestiviruses, namely, BVDV-1, BVDV-2 and BDV (2008)
A direct-ELISA for serodiagnosis of brucellosis in sheep and goats was developed and validated (2008)
A diagnostic Real-time PCR based on DNA polymerase gene has been developed and validated using suspected clinical samples of Capri poxviruses obtained from sheep and goats (2008)
A post-milking herbal teat dip for prevention of bovine mastitis was developed (2008)
A cart for rehabilitation of dogs suffering from posterior paresis has been designed and developed (2008).

B. LIVESTOCK IMPROVEMENT / MANAGEMENT

Introduction of Japanese quail (Coturnix coturnix japonica) as an alternate to poultry for the first time (1974) in India
Development and release of a high yielding broiler (B77) of poultry (1977)
Development of urea-molasses liquid feed and urea-molasses mineral liquid supplement for efficient utilization of low grade straws by ruminants (1980-85)
Evolution of new strains of high yielding cattle (3000-3500 kg of milk / 300 days of lactation) (1986-97)
Utilization of agro-industrial by-products like mahua cake, neem seed cake, sal seed meal, tomato pumace, etc. and unconventional feed stuffs as livestock feed (1990-95)
Development of a promising diet for growing pigs and feeding standards for buffaloes, rabbits and guinea fowls (1990-95)

The feeding of lactics (lactic acid bacteria) to pre-ruminant calves and yeast to adult ruminants was found to improve animal productivity (1995-2000)
Designing and fabrication of a simple field diagnostic tool ‘Crystoscope’ indigenously for assessing the optimum insemination time and categorization of bulls based on crystallization patterns of cervical mucous and neat semen (1999)
A combined PCR-SSCP, PCR-RFLP, microsatellite and heteroduplex analysis and DNA sequencing were successfully used for genotyping of animals (2001)
Regression of thyroid gland activity with decreased levels of thyroid hormones, T3 and T4 was observed in goats infected with PPR and liverfluke infection caused by F. gigantica (2001)
A pregnancy-specific marker protein of placental origin in serum of pregnant goats has been characterized (2001)

Evaluation of sugarcane bagasse pith as a sole roughage during scarcity (2002)
Technology development for utilization of karanj cake, urea-ammoniated sugar cane bagasse and kitchen waste as livestock feed (2003)
Genotyping of various genes namely, IGF BP-3, IL-2, IL-10, NRAMP-1, DRB-3 and ITGB-2 genes that affect growth/ production performance and/or disease resistance was done in buffaloes and goats (2003)
Eupatorium sesquiterpene (ODA, 9-oxo-10,11–dehydroageropherone) identified as a potent inhibitory agent in ruminant methane formation (2003)
Development of a lifting device for sick and convalescent large animals (2003)
Restoration of fertility in endometric cows by autologus plasma and ketocytes (2004)
Development of a tractor operated animal carrier (2004)
Cloning and characterization of various genes namely, Mx-1 in poultry, lysozyme & interleukin-2 in cattle and prostaglandin E synthase, osteopontin, interferon-tau, αs-1, αs-2, β & k- casein in buffalo (2006)
Development of cross-bred cattle strain ‘Vrindavani’ (2006)

C. LIVESTOCK PRODUCTS TECHNOLOGY

Development of technologies for value aided recipe such as meat pickles (1982), buffalo meat sausage (1982), meat patties (1986), meat tikkas (1986), meat kofta (1987), rabbit meat products (1992), chicken nuggets (1997), milk sausages (1986), egg loaf (1997), meat based snacks, chicken meat chips, curls (2001), functional mutton nuggets (2007)
Development of improved techniques to extend the shelf-life of chicken meat chunks up to one week at ambient temperature (1998)
Development of restructured meat rolls from buffalo meat (1999)
Development of diet nuggets from broilers and culled broiler hens (2002)
Development of technologies for buffalo meat based idli and meat samosa (2003)
Development of technique for successful incorporation of pork skin/rind in emulsion based products (2003)
Development of a novel device ‘tandoor hook’ hanger for meat specialities (2003)
Development of low salt, low fat, medium fibre pork meat balls (2004)
Development of meat products of nutritional merit incorporating capsicum, carrot, radish, red chilli, linseed and soya (2006)

D. HUMAN RESOURCE DEVELOPMENT

Prior to conferment of Deemed University status to IVRI in 1983, a total of 851 scholars earned their postgraduate degrees from the institute (M.V.Sc.-570, Ph.D.-273, D.Sc.-8) including 103 scholars from 22 countries
The Deemed University, IVRI awarded 105 M.Sc., 1526 M.V.Sc., 720 Ph.D. degrees to P.G. scholars enrolled at this institute (1984-2009)
A total of 1559 field veterinary officers were awarded National Diploma certificates by IVRI before conferment of Deemed University status
The Deemed University IVRI awarded 537 National Diploma certificates to field Veterinary Officers (1984-2009)