Biological Product Division

Major Achievements

  • Development of technology for large scale production of goat tissue Rinderpest vaccine and cell culture RP vaccine.
  • Production and supply of Ranikhet disease ‘F’, R2B & Fowl Pox vaccines.
  • Production of African Horse Sickness Vaccine which as enabled eradication of this disease of equines in India.
  • Development and Large scale production & standardization of Anthrax spore vaccine and Black Quarter vaccine.
  • Development and Production of fowl spirochaetosis vaccine.
  • Development of lapinised swine fever vaccine.
  • Development of technology and production of sheep pox vaccine.
  • Development and Production of curative antirabic BPL inactivated vaccine.
  • Development and Production of chick embryo origin (Flury) strain vaccine for prophylaxis of dogs against rabies.
  • Development and Production of canine distemper vaccine.
  • Replacement of conventional HS broth vaccine with oil adjuvant vaccine having better immunizing capacity for 2-3 years in cattle.
  • Development and Production of enterotoxaemia vaccine for sheep.
  • Development and Production of Abortus Bang Ring Antigen.
  • Development & Production of heat concentrated mammalian Tuberculin, Avian Tuberculin, Mallein IDP & Mallein subcutaneous antigens.
  • Development & Production of the attenuated sheep pox vaccine using SPV/RF (Roumanian Strain fanar) and its standardization.
  • Development and production PPDs of Tuberculin, Johnin & Mallein.
  • Development and production of Diagnostics for Brucellosis viz. ABR, RBPT, SAT antigens & Brucella Positive serum.
  • Development and production of antigens and sera for diagnosis of Salmonellosis in birds viz. Sal. Pullorum. Coloured antigen, Plain antigen, Sal.Positive sera & Sal. ‘O’ sera.
  • Development and standardization of production technology of inactivated Rabies Cell culture vaccine using PV-11 strain of rabies fixed virus grown in BHK 21 clone 13-cell line.
  • PPR vaccine developed at IVRI Mukteswar was scaled-up for large scale production and revenue generation.
  • Capacity building of state veterinary biological units and industries for self sufficiency of veterinary biologicals in country.
  • The production technologies of these vaccines and antigens have been transferred to various Biological Production Centres of the State & SAARC countries through NDBP and other short term training course conducted in the division.

Recent Research Achievements:

  • Development of PPR and Sheepox combined vaccine.
  • Process for production and upscaling of thermotolerant PPR vaccine using modified stabilizer combinations and optimized freeze-drying.
  • Adaptation and development of challenge virus strain (CVS) of Rabies in BHK21 cell line as a vaccine candidate.
  • Developed a Mab resistant mutant of PPRV Sungari/96 vaccine virus that can be differentiated from other strains by nucleic acid-based techniques.
  • Established Reverse Genetics system for rescue of Indian vaccine strain of classical swine fever virus (CSFV) in cell culture.
  • Developed green fluorescence tagged classical swine fever virus (CSFV) useful for live viral kinetics.
  • Recombinant Sheeppox virus expressing immunogenic gene of PPR virus had been generated for evaluation as a bivalent vaccine candidate.
  • Identified and evaluated native viral promoters of Sheepox virus (SPPV) for expression of heterologous gene in SPPV infected cell line.
  • The thymidine kinase (TK) knocked-out Vero Cell line developed through CRISPR-Cas9 technique.
  • N-gene based RT-PCR for detection of CDV nucleic acid developed. Identified a new lineage of CDV (India1/Asia5) through H gene based molecular epidemiology.
  • Isolation, characterization and passaging of recently circulating CDV from dog for development of vaccine candidate.
  • Generation of CDV specific monoclonal antibodies suitable for diagnostic applications.
  • Rapid visual detection of Brucella sps by polymerase spiral reaction (PSR) assay.
  • Developed of Brucella abortus S19 bacteriophage lysate as an inactivated vaccine candidate.
  • Development of Lateral flow device for detection of PPR virus antigen and antibody using identical LFA strip.

This is the official website of ICAR-Indian Veterinary Research Institute (ICAR-IVRI), Izatnagar, an institute under Indian Council of Agricultural Research (ICAR), Deparment of Agricultural Research & Education (DARE), Ministry of Agriculture and Farmers Welfare, Government of India.

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